JILA biophysicists apply tools and concepts from physics to the understanding of living systems at the molecular level, particularly in molecular biophysics, single-molecule biophysics, and biological force standards.
The field of biophysics promises answers to important questions about the structure, dynamics, function, and interactions of biological molecules such as proteins and nucleic acids. JILA scientists are developing unique ways to precisely measure the structure and function of individual proteins and nucleic acids, both of which are important molecules for living organisms. JILA scientists are also pioneering new methods to image and measure real-time biochemical activities within living cells and tissues. These research endeavors advance our understanding fundamental biological processes and support biomedical scientists in developing new drugs and diagnostics.
![The many different molecules trying to fill the binding site of octamethyl calix[4]pyrrole (omC4P)](/sites/default/files/styles/media_thumbnail_large/public/images/2025-04/weber_omc4p_thumbnail.jpg?h=fbf7a813&itok=e9ho_B28)
The Physics Frontiers Centers (PFC) program supports university-based centers and institutes where the collective efforts of a larger group of individuals can enable transformational advances in the most promising research areas. The program is designed to foster major breakthroughs at the intellectual frontiers of physics by providing needed resources such as combinations of talents, skills, disciplines, and/or specialized infrastructure, not usually available to individual investigators or small groups, in an environment in which the collective efforts of the larger group can be shown to be seminal to promoting significant progress in the science and the education of students. PFCs also include creative, substantive activities aimed at enhancing education, broadening participation of traditionally underrepresented groups, and outreach to the scientific community and general public.