Kinetic and Thermodynamic Control of G-Quadruplex Polymorphism by Na<sup>+</sup> and K<sup>+</sup> Cations

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Abstract

G-Quadruplexes (G4s) are ubiquitous nucleic acid folding motifs that exhibit structural diversity that is dependent on cationic conditions. In this work, we exploit temperature-controlled single-molecule fluorescence resonance energy transfer (smFRET) to elucidate the kinetic and thermodynamic mechanisms by which monovalent cations (K+ and Na+) impact folding topologies for a simple G-quadruplex sequence (5′-GGG-(TAAGGG)3-3′) with a three-state folding equilibrium.

Year of Publication
2023
Date Published
2023-07
Journal Title
The Journal of Physical Chemistry B
Volume
127
Start Page or Article ID
6842–6855
ISSN Number
1520-6106, 1520-5207
DOI
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