Kinetic and Thermodynamic Control of G-Quadruplex Polymorphism by Na<sup>+</sup> and K<sup>+</sup> Cations
| Author | |
| Abstract |
G-Quadruplexes (G4s) are ubiquitous nucleic acid folding motifs that exhibit structural diversity that is dependent on cationic conditions. In this work, we exploit temperature-controlled single-molecule fluorescence resonance energy transfer (smFRET) to elucidate the kinetic and thermodynamic mechanisms by which monovalent cations (K+ and Na+) impact folding topologies for a simple G-quadruplex sequence (5′-GGG-(TAAGGG)3-3′) with a three-state folding equilibrium. |
| Year of Publication |
2023
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| Date Published |
2023-07
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| Journal Title |
The Journal of Physical Chemistry B
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| Volume |
127
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| Start Page or Article ID (correct) |
6842–6855
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| ISSN Number |
1520-6106, 1520-5207
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| DOI | |
| Download citation | |
| JILA PI | |
| Associated Institutes | |
Journal Article
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| JILA Topics | |
| Publication Status |
The Physics Frontiers Centers (PFC) program supports university-based centers and institutes where the collective efforts of a larger group of individuals can enable transformational advances in the most promising research areas. The program is designed to foster major breakthroughs at the intellectual frontiers of physics by providing needed resources such as combinations of talents, skills, disciplines, and/or specialized infrastructure, not usually available to individual investigators or small groups, in an environment in which the collective efforts of the larger group can be shown to be seminal to promoting significant progress in the science and the education of students. PFCs also include creative, substantive activities aimed at enhancing education, broadening participation of traditionally underrepresented groups, and outreach to the scientific community and general public.