The availability of exascale computing resources has enabled numerical modeling of astrophysical fluid dynamics at unprecedented scale, including studies of MHD turbulence on grids with 10,000^{3} cells, or MHD models of black hole accretion in full GR with radiation transport. Results from a diverse range of applications will be presented, including new insights into the structure of radiation-dominated accretion disks, modeling AGN feedback in elliptical galaxies, and turbulence and cosmic ray transport in the interstellar medium.