@article{13213,
keywords = {Pulmonary and Respiratory Medicine},
author = {Qizhong Liang and Ya-Chu Chan and Jutta Toscano and Kristen Bjorkman and Leslie Leinwand and Roy Parker and Eva Nozik and David Nesbitt and Jun Ye},
title = {Breath analysis by ultra-sensitive broadband laser spectroscopy detects SARS-CoV-2 infection},
abstract = {Abstract
Rapid testing is essential to fighting pandemics such as coronavirus disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exhaled human breath contains multiple volatile molecules providing powerful potential for non-invasive diagnosis of diverse medical conditions. We investigated breath detection of SARS-CoV-2 infection using cavity-enhanced direct frequency comb spectroscopy (CE-DFCS), a state-of-the-art laser spectroscopic technique capable of a real-time massive collection of broadband molecular absorption features at ro-vibrational quantum state resolution and at parts-per-trillion volume detection sensitivity. Using a total of 170 individual breath samples (83 positive and 87 negative with SARS-CoV-2 based on reverse transcription polymerase chain reaction tests), we report excellent discrimination capability for SARS-CoV-2 infection with an area under the receiver-operating-characteristics curve of 0.849(4). Our results support the development of CE-DFCS as an alternative, rapid, non-invasive test for COVID-19 and highlight its remarkable potential for optical diagnoses of diverse biological conditions and disease states.
},
year = {2023},
journal = {Journal of Breath Research},
volume = {17},
pages = {036001},
month = {2023-04},
publisher = {IOP Publishing},
issn = {1752-7155, 1752-7163},
url = {https://iopscience.iop.org/article/10.1088/1752-7163/acc6e4},
doi = {10.1088/1752-7163/acc6e4},
}